Secretariat, Alumni Association, IDAC
Date	Tuesday, 24 December 2024, 16:00～
Room	7th floor, Seminar Room (1), IDAC Center for Aging Research
Title	Elucidating the Origin of Blood cells and the Role of Niche　Driving Blood Malignancies
Speaker	Feng Jue
Affiliation	Assistant Professor Department of Pharmacological Sciences Icahn School of Medicine at Mount Sinai
Organizer	Natsuko Chiba　( Department of Cancer Biology,ext.8477）
Abstract	We study the mechanisms of normal and malignant hematopoiesis using innovative genetic tools and models. Our DNA barcoding system, “FlipJump,” combined with CITE-seq, tracks in vivo development of dendritic, lymphoid, and myeloid cells from hematopoietic stem cells (HSCs), revealing a shared origin for cDCs and pDCs from Cx3cr1+ progenitors and underscoring HSCs’ central role across hematopoietic lineages. Additionally, our gene-editing models show that deletions in the 9p21-syntenic locus lead to a fatal MDS/MPN-like disease, originating in the bone marrow (BM) stroma, with fibrosis and extra trabecular bones. These insights aim to inform new therapeutic strategies for hematologic disorders. 1. Jue Feng et al. Clonal barcoding of endogenous adult hematopoietic stem cells reveals a spectrum of lineage contributions. PNAS. 2024. 2. Jue Feng et al. Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment. Blood. 2023 3. Jue Feng et al. Clonal lineage tracing reveals shared origin of conventional and plasmacytoid dendritic cells. Immunity. 2022