| Date |
Thursday, 12 December 2024, 16:00～ |
| Room |
7th floor, Seminar Room (1), IDAC Center for Aging Research |
| Title |
Epigenetic regulation of mouse sex determination |
| Speaker |
Prof. Makoto Tachibana |
| Affiliation |
Graduate School of Frontier Biosciences, Osaka University |
| Organizer |
Yohei Hayashi (Cell Resource Center for Biomedical Research, ext 8572)
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| Abstract |
In mammals, the expression of the sex-determining gene Sry on the Y chromosome during the fetal period determines the fate of sexually undifferentiated gonads to differentiate into testes (sex determination). In mice, Sry is expressed only in a small subset of somatic cells in the sexually undifferentiated gonads of 11.5-day post-fertilization embryos. The mechanism that underlies such temporally and cell-type specific expression of Sry had remained unknown We previously revealed that the removal of H3K9me2 by the histone demethylase KDM3A plays an essential role in the activation of mouse Sry. The removal of H3K9me2 by KDM3A requires ferrous iron (Fe2+). Recently, we discovered that genes involved in iron uptake and Fe2+ production are highly expressed in the gonadal somatic cells that express Sry. In this presentation, we will introduce our latest research findings on the role of iron metabolism in the epigenetic control of mouse sex determination.
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