| Date |
Tuesday, 10 September 2024, 16:00～ |
| Room |
7th floor, Seminar Room 1, IDAC Center for Basic Aging Research |
| Title |
Cell biological mechanisms of egg aneuploidy |
| Speaker |
Tomoya Kitajima |
| Affiliation |
Laboratory for Chromosome Segregation, RIKEN Center for Biosystems Dynamics Research (BDR) |
| Organizer |
Kozo Tanaka (Department of Molecular Oncology, ext 8491)
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| Abstract |
Egg aneuploidy in relatively small chromosomes is a major cause of pregnancy loss and congenital diseases such as Down syndrome. Egg aneuploidy is produced by meiotic chromosome segregation errors in oocytes. Oocytes exhibit errors more frequently than other cell types, and the error rate increases with age. Interestingly, smaller chromosomes are more error prone in aged oocytes, but the underlying mechanisms are poorly understood. We have recently established a ‘chromosome identifying-and-tracking’ technique throughout meiosis in live mouse oocytes. Quantitative analysis showed that smaller chromosomes are preferentially located in the inner region of the spindle equator. In aged oocytes, this interior positioning facilitates premature chromosome separation, thereby increasing a risk of chromosome segregation errors. We would like to discuss our recent development of artificial kinetochores, which may provide a technical basis to prevent egg aneuploidy.
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