Secretariat, Alumni Association, IDAC
Date	Monday, 18 November 2024, 16:00～
Room	7th floor, Seminar Room 1, IDAC Center for Basic Aging Research
Title	Beyond NAD World 3.0 Multi-Layered Inter-Organ Communications between the Hypothalamus and Peripheral Tissues in Mammalian Aging and Longevity Control
Speaker	Shin-ichiro Imai, MD, PhD　Theodore and Bertha Bryan Distinguished Professor in Environmental Medicine
Affiliation	Department of Developmental Biology, Department of Medicine (Joint) Washington University School of Medicine, St. Louis, USA
Organizer	Akiko Satoh (Department of Integrative Physiology, ext.8544)
Abstract	In mammals, we have demonstrated that the inter-organ communication between the hypothalamus and white adipose tissue (WAT) plays a critical role in counteracting aging and promoting longevity (Yoshida et al., 2019; Tokizane et al., 2024). This inter-organ communication is mediated by a specific neural population in the dorsomedial hypothalamus (DMH), named DMHPpp1r17 neurons, and extracellular nicotinamide phosphoribosyltrasferase, the rate-limiting NAD+ biosynthetic enzyme in mammals, which are encapsulated in extracellular vesicles and secreted from WAT (eNAMPT-EVs). With these findings, we have reformulated the “NAD World” concept to the next version, NAD World 3.0, in which we speculate that several multi-layered feedback loops between the hypothalamus and peripheral tissues are the core machinery for mammalian aging and longevity control. We have recently identified a novel myokine that mediates another inter-organ communication between skeletal muscle and the hypothalamus and promotes longevity in mice. All these new findings demonstrate the importance of multi-layered inter-organ communications between the hypothalamus and peripheral tissues in mammalian aging and longevity control. Based on such systemic understanding of aging and longevity control, a new anti-aging intervention will be proposed.