◇ 2024年11月18日（月）午後4時～ 加齢研セミナーのご案内
| 日時： | 令和6年11月18日（月）午後4時～ |
| 場所： | 加齢医学研究所実験研究棟7階 セミナー室(1) |
| 演題： | Beyond NAD World 3.0 Multi-Layered Inter-Organ Communications between the Hypothalamus and Peripheral Tissues in Mammalian Aging and Longevity Control |
| 講師： | 今井 眞一郎 テオドール＆バーサ•ブライアン卓越教授(環境医学) |
| 所属： | ワシントン大学医学部発生生物学部•医学部（兼任） |
| 担当： | 佐藤亜希子（所属 統合生理学研究分野・内線8544） |
| 要旨： | In mammals, we have demonstrated that the inter-organ communication between the hypothalamus and white adipose tissue (WAT) plays a critical role in counteracting aging and promoting longevity (Yoshida et al., 2019; Tokizane et al., 2024). This inter-organ communication is mediated by a specific neural population in the dorsomedial hypothalamus (DMH), named DMHPpp1r17 neurons, and extracellular nicotinamide phosphoribosyltrasferase, the rate-limiting NAD+ biosynthetic enzyme in mammals, which are encapsulated in extracellular vesicles and secreted from WAT (eNAMPT-EVs). With these findings, we have reformulated the “NAD World” concept to the next version, NAD World 3.0, in which we speculate that several multi-layered feedback loops between the hypothalamus and peripheral tissues are the core machinery for mammalian aging and longevity control. We have recently identified a novel myokine that mediates another inter-organ communication between skeletal muscle and the hypothalamus and promotes longevity in mice. All these new findings demonstrate the importance of multi-layered inter-organ communications between the hypothalamus and peripheral tissues in mammalian aging and longevity control. Based on such systemic understanding of aging and longevity control, a new anti-aging intervention will be proposed. |