| Date |
Monday, 3 June 2024, 16:00～ |
| Room |
7th floor, Seminar Room 1, IDAC Center for Basic Aging Research |
| Title |
Molecular function/regulation of Chromosomal SUMOylation in mitosis for accurate genome transmission. |
| Speaker |
Yoshiaki Azuma |
| Affiliation |
Department of Molecular Biosciences, University of Kansas |
| Organizer |
Kozo Tanaka (Department of Molecular Oncology, ext 8491) |
| Abstract |
Chromosome segregation during mitosis is a fundamental process in which the replicated genome is evenly inherited by two daughter cells. Post-translational modification by SUMO (SUMOylation) has shown to be essential for this genome transmission process in eukaryotes as such either inhibition of SUMOylation or deSUMOylation in mitosis causes mis-segregation of chromosomes. Many chromosomal proteins were identified as mitotic chromosomal SUMOylated proteins, including DNA Topoisomerase IIα (TopoIIα) and several CENPs. Currently, assembly of protein complex composed with SUMOylated protein and SUMO-interacting motif (SIM) containing proteins is proposed to be a major role of SUMOylation, the molecular function of the SUMOylation of each target proteins are still under investigation. This presentation, I will discuss our finding for molecular functions of mitotic SUMOylation on chromosome segregation by focusing its role on regulation of mitotic checkpoint activities and potential novel regulation by SUMO-targeting remodeling enzyme. |
